A novel approach of organometallic compounds towards the construction of nanoparticles for cancer therapy to enhance cellular uptake by targeting nucleus and mitochondria was achieved. By mixing the organometallic compound with a biocompatible polymer, PEG50 in a proper ratio coordination driven self- assembly occurs, to yield micelles. Bond formation between Pt and carboxylate ligands confirmed with 1HNMR and 31PNMR studies. Drug loading capacity within micelles found to be 80%. Cytotoxicity studies were carried out with MTT experiments, cellular uptake and cell imaging experiments. Mechanism of action of the micelles was studied with apoptosis, γH2AX, Mitostatus and MitoSOX assays. Results reveal that synthesized nanoparticles show better therapeutic effects on several cancer types including ovarian cancer.