This paper explores the confluence of art using telepresence, the technologically-mediated ability to act at a distance, and activism through individual artworks by new media artist Lynn Hershman Leeson and the cyberfeminist art collective subRosa, both of which explore the relationship of women and gender to issues of the body and cloning. Ultimately, I will argue not only for the promise of a new form of digitally-mediated subjectivity (the hyper-subject), but for the dire need for new forms of activism for women at the frontier of an existence both virtually and physically digitized.